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Dr. Anna

Exosomes & PRP

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Exosome Therapy

What are exosomes?

Exosomes are extracellular micro-vesicles that are involved in direct cell to cell communication.

Exosomes are not cells – they are tiny lipid vesicles that are secreted from a cell and are about 1/1,000th the size of a cell.

These are harvested from bone marrow of donors

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How do exosomes work?

Exosomes, sometimes called small bubbles or extracellular vesicles, are typically released from stem cells and act as transporters.

The cargo they carry between cells is genetic data and is used to propagate this data throughout the entire body.

This data typically carries simplistic instructions, telling each cell how to react.

By exposing the cells of an older organism to those of a younger organism we can see that exosomes from the young stem cells are responsible for rejuvenating the older cells.

Why exosomes over stem
cells themselves?

A degenerative disease comes from a continuous deterioration of cells, affecting tissues or organs. While stem cells are usually responsible for the rejuvenation of the cells, external factors may hinder the stem cells in this function. They may not be able to supply all the information needed.

Supporting their function with external exosomes could have a greater positive effect, by providing new pieces of information to support the healing process.

What is the process?

1.Injection- exosomes will be injected directly into the joint space of your knees

2.Activation- the injection strengthens the communication of cells, enables hundreds of cell growth factors, and enhances proteins to stimulate quicker healing and reduce inflammation.

3.Relief- While there may be soreness, redness, and/or discomfort at the area of injection for a few days; patients typically resume their usual daily activities.

Any known side effects?

As the therapy is usually performed relatively quickly and in an out-patient arrangement, most leave the clinic without any downtime needed to rest and recuperate. Some have reported experiencing headaches, nausea, mild fever, or vomiting but the amount of these reports are for the most part, minor. Nevertheless; these adverse effects have never exceeded three days with most of them resolving within 24 hours. Aside from these side-effects, there have been no long-term side-effects reported after treatment.

Things to know before getting injection

  • Avoid anti-inflammatory medication 2-3 days prior
  • Preferable to not had a steroid injection in last 3 weeks
  • Avoid stressful activity within the first 48 hours
  • Start cardio workouts after four weeks post-procedure

Platelet Rich Plasma

What are platelets?

Small, non-nucleated bodies in blood, primarily known for clotting.

Also contain proteins, cytokines, and bioactive markers that help in tissue and wound healing.

How do platelets work?

They deliver the following growth factors and molecules to injured sites:

  • Chemokines
  • Extracellular matrix proteins
  • Nucleotides
  • Ascorbic acid

Growth factors contribute to the platelets ability to assist in:

  • Bone remodeling
  • Proliferation
  • Vessel remodeling
  • Angiogenesis
  • Coagulation
  • Cell differentiation

So what is PRP?

PRP stands for platelet-rich plasma. Platelets are the components of your blood that are best known for blood clotting. Blood is made up of 55% plasma, 45% red blood cells, and about 1% white blood cells and platelets. Platelets also contain hundreds of proteins called growth factors, which are important in the healing of injuries. PRP is the separation of those platelets and plasma from the rest of the blood, which results in a high concentration of the platelets within the plasma, hence, platelet-rich plasma.

How does PRP work?

The various processes through which PRP treatments activate healing are highly complex. In the simplest terms, PRP injections activate the same processes the body would normally use, but amplified many times over.

For example, platelets tamp down inflammation cells and enhance cellular growth, while growth factors activate the healing of bone and soft tissue.

Indications for PRP Am I a candidate?

Ortho indications include:

  • Tendonitis/tendinopathy
  • Muscle tear/injury
  • Osteoarthritis
  • Bursitis
  • Can be used as a booster with stem cell therapy

Will I need to have this done more than once?

Depends on the severity of injury and the patient

We can repeat every 2-3 weeks up to 3 times in a 6 month period

What are common side effects?

Common side effects include pain and/or ache in the injection site, swelling and bruising.

How do I need to prepare for the procedure?

No corticosteroids for two to three weeks prior to the procedure

Discontinue NSAIDs one week prior to the procedure. Traditional NSAIDs include:

  • Aspirin
  • buprofen
  • Naproxen
  • Nabumetone

No anticoagulation use five days prior to the procedure

Increase fluid intake in the 24 hours prior to the procedure

What should I expect after the procedure?

Common to feel pain/discomfort for 24-48 hours post-injection

No high impact activity for 2 weeks

Rule of thumb after procedure during recovery time is if it hurts- don’t do it!

Contact Info

Address: 3316 Andrews Hwy, Midland, TX 79703

E-mail: info@regenpb.com

Phone : 432-688-1900