Exosomes are extracellular micro-vesicles that are involved in direct cell to cell communication.
Exosomes are not cells – they are tiny lipid vesicles that are secreted from a cell and are about 1/1,000th the size of a cell.
These are harvested from bone marrow of donors
Exosomes, sometimes called small bubbles or extracellular vesicles, are typically released from stem cells and act as transporters.
The cargo they carry between cells is genetic data and is used to propagate this data throughout the entire body.
This data typically carries simplistic instructions, telling each cell how to react.
By exposing the cells of an older organism to those of a younger organism we can see that exosomes from the young stem cells are responsible for rejuvenating the older cells.
A degenerative disease comes from a continuous deterioration of cells, affecting tissues or organs. While stem cells are usually responsible for the rejuvenation of the cells, external factors may hinder the stem cells in this function. They may not be able to supply all the information needed.
Supporting their function with external exosomes could have a greater positive effect, by providing new pieces of information to support the healing process.
1.Injection- exosomes will be injected directly into the joint space of your knees
2.Activation- the injection strengthens the communication of cells, enables hundreds of cell growth factors, and enhances proteins to stimulate quicker healing and reduce inflammation.
3.Relief- While there may be soreness, redness, and/or discomfort at the area of injection for a few days; patients typically resume their usual daily activities.
As the therapy is usually performed relatively quickly and in an out-patient arrangement, most leave the clinic without any downtime needed to rest and recuperate. Some have reported experiencing headaches, nausea, mild fever, or vomiting but the amount of these reports are for the most part, minor. Nevertheless; these adverse effects have never exceeded three days with most of them resolving within 24 hours. Aside from these side-effects, there have been no long-term side-effects reported after treatment.
Small, non-nucleated bodies in blood, primarily known for clotting.
Also contain proteins, cytokines, and bioactive markers that help in tissue and wound healing.
They deliver the following growth factors and molecules to injured sites:
Growth factors contribute to the platelets ability to assist in:
PRP stands for platelet-rich plasma. Platelets are the components of your blood that are best known for blood clotting. Blood is made up of 55% plasma, 45% red blood cells, and about 1% white blood cells and platelets. Platelets also contain hundreds of proteins called growth factors, which are important in the healing of injuries. PRP is the separation of those platelets and plasma from the rest of the blood, which results in a high concentration of the platelets within the plasma, hence, platelet-rich plasma.
The various processes through which PRP treatments activate healing are highly complex. In the simplest terms, PRP injections activate the same processes the body would normally use, but amplified many times over.
For example, platelets tamp down inflammation cells and enhance cellular growth, while growth factors activate the healing of bone and soft tissue.
Ortho indications include:
Depends on the severity of injury and the patient
We can repeat every 2-3 weeks up to 3 times in a 6 month period
Common side effects include pain and/or ache in the injection site, swelling and bruising.
No corticosteroids for two to three weeks prior to the procedure
Discontinue NSAIDs one week prior to the procedure. Traditional NSAIDs include:
No anticoagulation use five days prior to the procedure
Increase fluid intake in the 24 hours prior to the procedure
Common to feel pain/discomfort for 24-48 hours post-injection
No high impact activity for 2 weeks
Rule of thumb after procedure during recovery time is if it hurts- don’t do it!